A 44-year-old man sought care in the emergency department of Virginia Commonwealth University Medical Center (Richmond, VA, USA) in June 2020 after experiencing 3 days of severe, diffuse headache, and subjective fevers; maximum measured temperature was 37.9°C. In 1986, the patient had undergone a living related donor kidney transplant for end-stage renal disease related to focal segmental glomerulosclerosis. He underwent another living related donor transplant in 1999 and a deceased-donor transplant in 2010 after the previous allografts failed. His most recent transplant, which occurred 10 years before the illness documented in this study, was performed with thymoglobulin induction and had been maintained with an immunosuppressive regimen of tacrolimus (goal trough of 5–7 ng/mL at the time of this hospitalization), 180 mg mycophenolic acid (2×/d), and 10 mg prednisone (1×/d). His medical history was further notable for seizure disorder and an allergy to penicillin, which manifested as severe urticaria.
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